Synthesis of Halogen Substituted Chalcone Againts Cervical Cancer (HeLa) Cell Lines using Green Method

Cervical cancer is the second leading cause of death in women. Many treatments currently provide toxic effects on normal cells. Therefore, alternative treatment using chalcone derivatives has potent anticancer properties that can help reduce side effects. Chalcone with halogen and methoxy groups ring B potentially inhibit This research aimed to synthesize halogen-substituted by a green chemistry approach determine activity against cervical (HeLa) cell lines. The Claisen-Schmidt reaction was used 2'-hydroxy-2-bromo-4,5-dimethoxychalcone grinding technique. purity synthesized compound determined thin-layer chromatography melting range. compounds' structures were characterized FTIR, MS 1H, 13C-NMR. result showed yielded 53% as yellow solid. In vitro cytotoxicity evaluated MTT assay method. IC50 67,23 μg/mL moderate inhibiting Based value, this be candidate for lines